PTMs	post-translational modifications
Kla	Lactylation
GPR81	Gi-protein-coupled receptor 81
TME	tumor microenvironment
HDAC	histone deacetylase
CBP	CREB-binding protein
HDAC	histone deacetylase
SIRT	sirtuins
La	lactyl;’
NSCLC	non-small cell lung cancer
ATP	adenosine triphosphate
NADH	nicotinamide adenine dinucleotide
TCA	tricarboxylic acid
LDH	lactate dehydrogenase
AMPK	AMP-activated protein kinase
AKT	activating protein kinase B
KLF4	kruppel-like factor 4
NF-κB	nuclear factor-kappa B
MCT1	moncarboxylate transporter 1
TAM	tumor-associated macrophages
VEGF	vascular endothelial-derived growth factor
Arg1	arginase 1
CTLs	cytotoxic T lymphocytes
NK	Natural killer
NKT	Natural killer T
IFNγ	interferon-γ
IL	interleukin
PDK	pyruvate dehydrogenase kinase
DCA	dichloroacetic acid
MGO	methylglyoxal
LGSH	lactoylglutathione
GLO1	glyoxalase 1
ALDOA	aldolase A
AK2	adenylate kinase 2
HCC	hepatocellular carcinoma
HIF-1α	hypoxia-inducible factor alpha
PHD	proline hydroxylase
ENO1	enolase
HK-1	hemokinin-1
PKM	pyruvate kinase M
SDHA	succinate dehydrogenase
IDH3G	isocitrate dehydrogenase 3 gamma
TGF	transforming growth factor
LPS	lipopolysaccharide
PI3K	phosphatidylinositol-3 kinase
TIMs	tumor-infiltrating myeloid cells
METTL3	methyltransferase-like 3
JAK1	janus kinase
PykF	pyruvate kinase I
HP	helicobacter pylori
TLR	toll-like receptors
YY1	yin-yang 1
SDH	succinate dehydrogenase
IDH	lactate dehydrogenase
CCNE2	cyclin E2
PCSK9	proprotein convertase subtilisin-kexin type 9
MIF	macrophage migration inhibitory factor
VHL	von Hippel-Lindau
ccRCC	clear cell renal cell carcinoma
PDGFRβ	platelet-derived growth factor receptor β
YTHDF2	YT521-B homology domain family member 2
PD-1	programmed cell death protein 1
NFAT1	nuclear factor of activated T cells 1
MDSCs	myeloid-derived suppressor cells
STAT3	signal transducer and activator of transcription 3
FoxP3	Forkhead/winged helix transcriptional factor P3
MHC	major histocompatibility complex
LND	lonidamine