Figure 5.

Reduction of capsaicin-induced mechanical hypersensitivity by the systemic administration of the experimental compounds and BD-1063 as standard S1R antagonist in mice, and contribution of S1R to their effects. (A) Dose dependency of the antinociceptive effects of the subcutaneous (s.c.) administration of BD-1063, 8a, 9a, 9d, 14a, and 15a. (B) Effects of the compounds tested alone and associated with the S1R agonist PRE-084. Values are the mean ± SEM obtained from 6–9 animals per group: *p < 0.05, ^**p < 0.01 vs non-sensitized animals treated with the solvent of the drugs (black bar); ^#p < 0.05, ^##p < 0.01 vs capsaicin-injected mice treated with the solvent of the drugs (white bar); ⁺p < 0.05, ⁺⁺p < 0.01 selected doses of each compound associated with PRE-084 or its solvent (one-way ANOVA followed by Student–Newman–Keuls test).