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. 2023 Aug 3;66(16):11133–11157. doi: 10.1021/acs.jmedchem.3c00575

Table 5. Kinase-Inhibitory and Antiproliferative Activities of Imidazo[1,2-b]pyridazine Derivatives.

	IC₅₀ (μM)^a			GI₅₀ (μM)^a
	FLT3-ITD	FLT3-D835Y	CDK2/E	MV4-11	MOLM-13	SEM	CEM	NOMO-1	ML-2	K562
29a	0.002	0.002	0.003	0.0001	0.004	0.008	0.623	0.240	0.118	0.320
29b	0.005	0.004	0.037	0.001	0.024	0.225	1.073	1.380	0.596	0.722
30	0.006	0.012	0.211	0.279	0.070	0.655	1.910	4.875	3.100	1.363

^a

For SD values, see Table S3 in the Supporting Information.