Table 7. Kinase-Inhibitory and Antiproliferative Activities of Imidazo[1,2-b]pyridazine Derivatives.

	IC50 (μM)a			GI50 (μM)a
	FLT3-ITD	FLT3-D835Y	CDK2	MV4-11	MOLM-13	SEM	CEM	NOMO-1	ML-2	K562
34a	0.007	0.004	0.196	0.005	0.007	0.372	3.800	8.430	5.780	6.870
34b	0.005	0.002	0.005	0.008	0.007	0.235	0.917	0.620	0.480	0.885
34c	0.008	0.002	0.083	0.028	0.030	0.453	3.727	2.435	1.078	1.725
34d	0.004	0.001	0.011	0.005	0.009	0.210	0.810	0.848	0.490	0.635
34e	0.009	0.002	0.093	0.005	0.007	0.132	0.683	0.700	0.455	1.310
34f	0.004	0.001	0.493	0.007	0.009	0.140	1.768	4.275	3.030	1.525
34g	0.001	0.002	2.119	0.045	0.040	0.283	2.645	5.223	3.505	1.640
34h	0.002	0.002	0.961	0.073	0.176	1.060	6.170	>10	6.865	1.010
34i	0.002	0.006	1.435	0.060	0.027	0.877	6.380	5.085	4.220	2.255
34j	0.001	0.001	0.234	0.023	0.030	0.150	1.690	5.030	2.050	1.063
34k	0.001	0.002	0.037	0.017	0.019	0.590	1.940	0.865	0.325	2.120
34l	0.004	0.011	1.443	0.156	0.200	1.031	1.570	5.025	3.923	1.505
34m	0.013	0.025	6.587	0.790	0.410	1.335	4.750	4.260	3.310	1.550
34n	0.001	0.002	0.366	0.042	0.025	0.168	0.760	0.393	0.245	1.655
34o	0.231	0.569	3.428	0.710	0.935	2.525	8.990	9.035	4.475	>10
34p	0.142	0.834	2.435	1.183	1.160	1.500	8.400	2.385	2.000	4.128
34q	0.001	0.003	0.082	0.002	0.004	0.381	1.400	1.455	0.440	1.470
34r	0.001	0.002	0.031	0.001	0.001	0.399	1.030	0.755	0.270	0.570
39	0.333	0.268	1.116	1.557	2.213	>10	>10	>10	>10	>10
42a	0.002	0.001	0.031	0.006	0.011	0.823	7.363	1.745	0.370	9.850
42b	0.106	0.014	0.178	0.039	0.097	0.523	1.423	4.733	3.650	5.545

^aFor SD values, see Table S3 in the Supporting Information.