Figure 6.

Structural dynamics of LA-PTH–PTH₁R complex. Overlaid 3 distinct conformational states of LA-PTH–PTH₁R complex obtained from cryo-EM data analysis, aligned by TMDs. PTH₁R and LA-PTH are shown as different shades of purple and orange, respectively. The oscillation of the PTH₁R^ECD is evident (close-up view), while the TMD core shows higher degree of stability, likely due to tight binding of ^NLA-PTH. Notably, state 3 captures the event of partial dissociation of ^CLA-PTH from PTH₁R^ECD (arrow).