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. 2023 Aug 14;14:1233800. doi: 10.3389/fimmu.2023.1233800

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Copyright © 2023 Knoedler, Broichhausen, Guo, Dai, Knoedler, Kauke-Navarro, Diatta, Pomahac, Machens, Jiang and Rinkevich

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Current conception of patch-like scar repair after deep skin wounds. Fascial engrailed-positive fibroblasts (EPFs) drag local composite matrix into the wound, with a collective migration pattern of EPFs underlying this conveyor belt-like steering. During this fascia mobilization, cell-cell adhesion and communication via N-cadherin and connexin43 (Cx43) play an integral role, facilitating swarm-like aggregation and ultimately sealing of the open wounds with dense plugs of pre-fabricated fascial matrix. Over time, this provisional fascia-derived skin barrier is remodeled into a mature (excessive) scar.