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. 2023 Aug 14;14:1196065. doi: 10.3389/fimmu.2023.1196065

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Copyright © 2023 Peng, Shen, Yu, Wu, Zha, Xia and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-200a could not provide colonic protection against DSS-induced acute colitis in Nrf2-deficient mice. (A) The timetable of the Nrf2 knockdown regime. (B, C) The protein expression of Nrf2 was detected in the colon after shRNA or shNrf2 treatment. GAPDH was used as a loading control. (D) Representative images of mice colon sections stained with H&E. (original magnifications, ×200, scale bars =50 μm; ×400, scale bars =20 μm). (E, F) The level of ROS and the activity of MDA in colon of shRNA or shNrf2 treated mice were detected by commercial kits. (G) The GSH/GSSG ratio in colon of shRNA or shNrf2 treated mice were detected by commercial kits. Data are provided as mean ± SEM and reflect six experiments, analyzed using one-way ANOVA with Tukey post-hoc analysis. ^∗P < 0.05; ns, not significant.