TABLE 1.
Performance characteristics of the H-ELISA, MV-ELISA, and whole-virus-based ELISAsa
| Assay (cohort) | Specificity (%) | Sensitivity (%) | Accuracy (%) | Prevalence (%) | Positive predictive value (%) | Negative predictive value (%) | Undefined sera (%) |
|---|---|---|---|---|---|---|---|
| H-ELISA (this studya) | 100 | 98.6 | 98.7 | 95.1 | 100 | 78.6 | 0.9 |
| MV-ELISA (this studya) | 45.5 | 99.5 | 96.9 | 95.1 | 97.2 | 83.3 | 0.9 |
| MV-ELISA (other studiesb) | 80.0–100 | 99.1–100 | 94.7–99.2 | 73.5–87.5 | 93.3–100 | 94.0–100 | 0–0.4 |
a
“Gold standards,” HI and NT.
b
Data are for undefined populations (8, 12) and high school children before an outbreak (34). For maximal comparability, the values were recalculated after adding the undefined sera to the negative sera by using the same algorithms (7). The minimal and maximal values obtained from the three previous studies (8, 12, 34) are presented.