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. Author manuscript; available in PMC: 2023 Aug 28.
Published in final edited form as: Pain. 2020 Jan;161(1):185–194. doi: 10.1097/j.pain.0000000000001710

Figure 4. Cold-selective SPB neurons have distinct membrane properties and small soma size.

Figure 4.

(A) Resting membrane potential of cold-selective SPB neurons is not different than other SPB neurons. Box plots are median and interquartile range with symbols representing data points from individual SPB neurons (n = 7 cold-selective SPB neurons from 7 mice and 20 other SPB neurons from 10 mice; n.s., p > 0.05, Wilcoxon test). (B) Membrane capacitance of cold-selective SPB neurons is significantly lower than that of other SPB neurons. Box plots are median and interquartile range with symbols representing data points from individual SPB neurons (n = 6 cold-selective SPB neurons from 6 mice and 14 other SPB neurons from 12 mice; * indicates p < 0.05, Wilcoxon test). (C) Membrane capacitance of cold-selective SPB neurons is significantly higher than that of other SPB neurons. Box plots are median and interquartile range with symbols representing data points from individual SPB neurons (n = 6 cold-selective SPB neurons from 5 mice and 14 other SPB neurons from 12 mice; ** indicates p < 0.01, Wilcoxon test). (D-E) Representative images (D) and quantification (E) of soma size from cold-selective SPB neurons compared to other SPB neurons. Box plots are median and interquartile range with symbols representing data points from individual SPB neurons (n = 5 cold-selective SPB neurons and 12 other SPB neurons; ** indicates p < 0.01, Wilcoxon test).