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. 1983 Jun;59(3):157–168. doi: 10.1136/sti.59.3.157

Experimental syphilis: guinea pig model.

C S Pierce, K Wicher, S Nakeeb
PMCID: PMC1046167  PMID: 6342707

Abstract

Outbred Hartley male guinea pigs (300-400 g) were infected intradermally with various concentrations of Treponema pallidum Nichols strain in the pubic region. The median lethal dose (ID50) was approximately 10(5). The animals produced lesions visible by darkfield microscopy, treponemal antibodies (IgG only), and histopathological changes in the lymphoid organs. Though less susceptible to T pallidum infection than the rabbit when infected with a sufficient number of organisms, the guinea pig may be a useful model in experimental syphilis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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