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. 2023 Aug 24;16:3669–3685. doi: 10.2147/JIR.S420747

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© 2023 Bu et al.

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Overexpression of HLA-G5 in hAMSCs ameliorated aGVHD in mice.

Notes: (A) Schematic diagram of the animal experimental design (Created with BioRender.com). (B–D) Changes of body weight (B), aGVHD clinical score (C) and survival curve (D) in different groups (n = 10). (E) Representative photomicrographs of H&E staining (400×) and histopathological scores (n = 4). (F) Representative photomicrographs of CD45 stained by immunohistochemistry (400×) and CD45 positive area proportion (n = 4). Mice in aGVHD that suffered severe aGVHD and mice in hAMSCs and HLA-G5 groups on day 6 after transplantation were sacrificed to harvest target organs and peripheral blood for H&E staining and immunohistochemical staining. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, based on the one-way ANOVA and Tukey’s post hoc test. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001, based on the Student’s t-test.

Abbreviation: ns, no significance.