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. 2023 Aug 24;17:2549–2571. doi: 10.2147/DDDT.S422770

Table 6.

The Top 10 Cited References Related to HBOCs

Rank Citations Title First Author Journal Year Country H-Index IF (2021) JCR (2021)
1 685 Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis Natanson C Jama 2008 USA 709 157.335 Q1
2 536 Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial Sloan EP Jama 1999 USA 709 157.335 Q1
3 489 Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin Doherty DH Nature Biotechnology 1998 USA 463 68.164 Q1
4 424 Oxygen carriers (“blood substitutes”)--raison d’etre, chemistry, and some physiology Riess JG Chemical Reviews 2001 USA 745 72.087 Q1
5 398 The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery Gould SA Journal of the American College of Surgeons 1998 USA 186 6.532 Q2
6 358 Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin Hess JR Journal of Applied Physiology 1993 USA 208 5.125 Q1
7 344 Oxygen therapeutics: can we tame haemoglobin? Alayash AI Nature Reviews Drug Discovery 2004 England 348 112.28 Q1
8 318 Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide Rohlfs RJ The journal of biological chemistry 1998 USA 528 5.486 Q2
9 302 MP4, a new nonvasoactive PEG-Hb conjugate Vandegriff KD Transfusion 2003 England 138 3.337 Q3
10 225 Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial Levy JH The journal of thoracic Cardiovascular Surgery 2002 USA 201 6.195 Q1

Abbreviations: HBOCs, hemoglobin-based oxygen carriers; IF, impact factor; JCR, journal citation reports; Q, quartile in category.