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. Author manuscript; available in PMC: 2023 Aug 28.
Published in final edited form as: Ann Rheum Dis. 2020 Jun 16;79(9):1234–1242. doi: 10.1136/annrheumdis-2019-216599

Table 4.

The top 10 up-regulated genes in each type of myositis compared to normal biopsies.

DM (All) Anti-Mi2 Anti-NXP2 Anti-MDA5 Anti-TIF1g AS (Jo1) IBM IMNM (All) Anti-HMGCR Anti-SRP
gene FC qval gene FC qval gene FC qval gene FC qval gene FC qval gene FC qval gene FC qval gene FC qval gene FC qval gene FC qval
ISG15 101 1.06E-91 IFI6 62 2.6E-43 ISG15 110 1.5E-55 ISG15 163 1.2E-51 ISG15 84 1.5E-47 PSMB8 13 2.64E-25 GBP2 7 1.27E-18 SERPINA3 22 1.63E-28 ACTC1 18 3.6E-31 SERPINA3 24 1.8E-17
IFI6 67 2.73E-80 ISG15 67 5.9E-43 IFI6 70 7.8E-48 IFI6 72 2.6E-37 IFI6 62 1.7E-43 ACTC1 18 2.33E-23 BIRC3 7 4.43E-18 ACTC1 15 1.08E-27 SERPINA3 20 5.8E-25 ACTC1 12 9.8E-13
MX1 29 2.58E-56 MX1 32 1.9E-33 RSAD2 23 2.1E-33 ZFHX2 18 9.9E-25 MX1 41 9.0E-39 GBP2 7 1.11E-22 PSMB8 9 1.70E-16 CHRNA1 8 6.40E-21 MYH3 17 8.1E-21 HP 18 1.6E-12
RSAD2 18 1.25E-49 OAS1 25 9.7E-28 MX1 29 8.6E-33 IFI35 30 2.3E-24 MX2 22 6.9E-32 SAA1 37 1.11E-22 GBP1 11 3.50E-16 IFITM10 9 3.20E-20 CHRNA1 7 2.0E-19 CHRNA1 9 2.7E-12
MX2 17 2.48E-49 MX2 18 1.2E-27 IFIT2 22 5.6E-31 ACP5 35 2.2E-23 OAS1 29 3.8E-31 SIK1 10 3.05E-21 CCL13 20 4.96E-16 TNC 11 5.38E-20 IFITM10 9 2.6E-19 TNC 11 6.7E-12
OAS1 23 4.00E-48 LY6E 16 4.5E-26 KLHDC7B 65 1.1E-30 SECTM1 26 1.0E-22 IFITM1 12 2.7E-28 NNMT 14 9.65E-21 ITGAL 9 2.47E-15 KRT80 13 1.35E-19 TNNT2 16 1.7E-18 DCLK1 7 6.7E-12
IRF9 10 2.54E-43 RSAD2 17 8.1E-26 OAS1 26 4.7E-30 ZBP1 42 1.6E-22 RSAD2 18 2.0E-27 MYH3 23 9.83E-21 GBP5 17 3.95E-15 TNNT2 15 1.35E-19 ANKRD1 10 2.4E-18 KRT80 13 6.7E-12
IFITM1 10 8.62E-43 CMPK2 15 2.2E-25 OAS3 16 1.3E-26 CLEC4GP1 19 5.4E-21 TYMP 30 2.0E-27 GADD45A 8 9.83E-21 HLA-DQA1 13 2.41E-14 MYH3 13 2.66E-19 CSPG4 5 2.4E-18 IFITM10 10 1.0E-11
CMPK2 13 4.24E-42 OAS3 16 3.6E-25 HERC5 25 3.4E-26 PSMB8 19 3.3E-20 IFI44 18 4.1E-27 GBP1 12 9.83E-21 CD8A 16 3.45E-14 ANKRD1 10 2.04E-18 TNC 10.06 2.6E-18 RUNX1 6.98 3.0E-11
OAS3 14 2.27E-41 KLHDC7B 39 3.0E-23 MX2 15 4.8E-26 IFI27 18 2.2E-19 DHX58 13 6.2E-27 IFI30 16 1.02E-20 HLA-DOA 10 3.58E-14 DCLK1 6 2.45E-18 KRT80 11.97 9.9E-18 TNNT2 13.81 3.3E-11

DM: dermatomyositis; AS: antisynthetase syndrome; IBM: inclusion body myositis; IMNM: inclusion body myositis; FC: fold-change; qval: adjusted p-value. The name and location of the genes is indicated in Supplementary Table 2.