Table 1.
Summary of nanobiolistics based studies in the animal systems
| Nanoparticle | Delivery metrics | |||||||
|---|---|---|---|---|---|---|---|---|
| Type | Size | Cargo | Target tissue/cell | Delivery pressure (psi) | Depth penetration | Cell damage | Transfection efficiency | Reference |
| Tungsten | 1.3 μm | – | Retinal progenitor cells | 75 | – | 12% | – | [77] |
| – | Retinal progenitor cells | 150 | – | 25% | – | |||
| Silver | 80 nm | – | Retinal progenitor cells | 250 | – | 2% | – | |
| Gold | 1 μm | EYFP DNA | HEK | 50 | – | 63.7 ± 3.5 μma | 27 ± 4% | [77] |
| 40 nm | EYFP DNA | HEK | 50 | – | 21.7 ± 1.3 μma | 25 ± 4% | ||
| 1 μm | NS | Mouse ear tissue | 75 | 50 ± 11 μm | 22 ± 3% | – | ||
| 40 nm | NS | Mouse ear tissue | 75 | 31 ± 6 μm | 9 ± 2% | – | ||
| Gold | 1 μm | EYFP DNA | Organotypic brain slices (OTPS) | 50 | – | 47% | 23% | [76] |
| 40 nm | EYFP DNA | OTPS | 50 | – | Negligible | 33% | ||
NS: not specified
a
Cell and tissue damage quantified using diameter of zone of dead cells dislodged by bombardment