Fig. 5.

Result of spectroscopic screening for a sample analyte-SWNT candidate nanosensor. (a) Fluorescence spectrum for a representative SWNT-polymer conjugate before (black) and after (red) addition of an analyte shown to induce fluorescence modulation. The peak at 1044 nm, for instance, can be used to calculate the sensor signal, (I-I₀)/I₀. (b) Simulated heat map of sensor response to the library of protein analytes. Candidate sensors with a significant turn-off or turn-on response to a single analyte are deemed selective synthetic antibodies, such as Protein B + candidate SWNT sensor 2, or Protein C + candidate SWNT sensor 4