Table 3.
Polyp frequency and prevalence in patients with metachronous CRC
| Total | Second BRAFV600E-CRC | Second BRAFwt-CRC | Serrated CRC + BRAFwt-CRC | |
| Patients, n | 8 | 3 | 3 | 2 |
| Total polyps, median number (IQR) | 22 (8.5–24.0) | 17.7 (14.7) | 14.0 (8.7) | 22.0 (2.8) |
| Conventional adenomas, median number (IQR)/mean (SD)a | 5.0 (0.5–9.5) | 4.3 (7.5) | 6.3 (3.2) | 5 (4.2) |
| Tubular adenomas | 4.0 (0.5–8.8) | 4.0 (6.9) | 5.3 (3.2) | 5 (4.2) |
| Tubulovillous adenomas | 1.0 (0–1.0) | 0.3 (0.6) | 1.0 (0) | 0 |
| Villous adenomas | 0 | 0 | 0 | 0 |
| Advanced adenomas, median number (IQR)/mean (SD) | 0 (0–1.0) | 0.3 (0.6) | 0.3 (0.6) | 0.5 (0.7) |
| Serrated polyps, median number (IQR)/mean (SD) | 15.0 (3.8–17.5) | 13.3 (11.2) | 7.6 (5.7) | 17.0 (1.4) |
| Hyperplastic polyps | 4.0 (1.3–9.8) | 9.3 (11.1) | 2.7 (3.1) | 6.5 (6.4) |
| Sessile serrated lesions | 5.0 (1.0–8.3) | 3.3 (4.9) | 4.3 (2.9) | 8.0 (7.1) |
| Traditional serrated adenomas | 0 | 0 (0) | 0 | 0 |
| Advanced serrated polyps, median number (IQR)/mean (SD) | 3.0 (0.0–5.5) | 3.7 (3.5) | 1 (1.7) | 4.5 (2.1) |
| At least 1 conventional adenoma | 6 (75.0) | 1 (33.3) | 3 (100) | 2 (100) |
| Tubular adenomas | 6 (75.0) | 1 (33.3) | 3 (100) | 2 (100) |
| Tubulovillous adenomas | 4 (50.0) | 1 (33.3) | 3 (100) | 0 |
| Villous adenomas | 0 | 0 | 0 | 0 |
| At least 1 advanced adenomas | 3 (37.5) | 1 (33.3) | 1 (33.3) | 1 (50.0) |
| At least 1 serrated polyp | 8 (100) | 3 (100) | 3 (100) | 2 (100) |
| Hyperplastic polyps | 7 (87.5) | 3 (100) | 2 (66.7) | 2 (100) |
| Sessile serrated lesions | 7 (87.5) | 2 (66.7) | 3 (100) | 2 (100) |
| Traditional serrated adenomas | 0 | 0 | 0 | 0 |
| At least 1 advanced serrated polyp | 5 (62.5) | 2 (66.7) | 1 (33.3) | 2 (100) |
CRC, colorectal cancer; IQR, interquartile range.
a
Low frequencies were presented in mean with SD.