FIG 1.

CCDI Working Group structure: The CCDI Working Groups provide important feedback on the crucial areas on which the initiative should focus. The Cohort Working Group is tasked with developing strategies and a series of initiatives (eg, capture historical data and ensure it is accessible and interoperable with the prospective data) to gather data from every patient diagnosed with a pediatric cancer in the United States. The Protocol Working Group provides expert guidance for the MCI screening protocol. The Cross-Cutting Working Group is focused on ensuring the effective collaboration, communication, and coordination of all activities for the CCDI. The Platform Working Group defines a strategy and approach for federating and/or integrating data to enable integrated analytics and incentivize researchers to use the data in new ways. CCDI, Childhood Cancer Data Initiative; MCI, Molecular Characterization Initiative.