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[Preprint]. 2023 Nov 29:2023.08.15.553416. Originally published 2023 Aug 17. [Version 3] doi: 10.1101/2023.08.15.553416

Figure 7. L1 trans-eQTLs are co-associated with aging traits in GWAS databases.

Figure 7.

(A) Scheme for obtaining trans-eQTL SNV-associated aging phenotypes from the Open Targets Genetics platform. (B) A pie chart representing the number of SNVs (222/499) associated with an aging-related MeSH trait, either by PheWAS or indirectly linked to the phenotype through a proxy lead SNP in LD with the SNV. (C) Histogram depicting the distribution of number of aging MeSH traits associated with the 222/499 SNVs by PheWAS. (D) Histogram depicting the distribution of number of aging MeSH traits linked with the 222/499 SNVs through a proxy lead SNP in LD with the SNVs. (E) A diagram highlighting the organ targets of the top 10 most frequently associated aging traits. (F) The concentrations of circulating IL16 in aging mice of both sexes was assessed by ELISA. Each dot represents an independent animal, with n = 15 - 17 per group. Significance across age in each sex was assessed using a Wilcoxon test. The p-values from each sex (females in pink and males in blue) were combined by meta-analysis using Fisher’s method. Any p-value < 0.05 was considered significant. Some panels were created with BioRender.com.