Reaction	Reaction rate	Reaction propensity
Gene A alleles, wildtype
$off\to on$	$r_{on}^A+r_{add}^{NITC}\frac{A_{nonsense}^n}{k^n+A_{nonsense}^n}$	$(r_{on}^A+r_{add}^{NITC}\frac{A_{nonsense}^n}{k^n+A_{nonsense}^n}){}^{\ast }off$
$on\to off$	$r_{off}$	$r_{off}^{\ast }on$
$on\to on+A_{wt}$	$r_{prod}$	$r_{prod}^{\ast }on$
$A_{wt}\to \varnothing$	$r_{deg}$	$r_{deg}^{\ast }{A}_{wt}$
Gene A alleles, nonsense mutant
$off\to on$	$r_{on}^A+r_{add}^{NITC}\frac{A_{nonsense}^n}{k^n+A_{nonsense}^n}$	$(r_{on}^A+r_{add}^{NITC}\frac{A_{nonsense}^n}{k^n+A_{nonsense}^n}){}^{\ast }off$
$on\to off$	$r_{off}$	$r_{off}^{\ast }on$
$on\to on+A_{nonsense}$	$r_{prod}$	$r_{prod}^{\ast }on$
$A_{nonsense}\to \varnothing$	$r_{deg}$	$r_{deg}^{\ast }{A}_{nonsense}$
Gene A’ alleles
$off\to on$	$r_{on}^{A^{\text{'}}}+r_{add}^{NITC}\frac{A_{nonsense}^n}{k^n+A_{nonsense}^n}$	$(r_{on}^{A^{\text{'}}}+r_{add}^{NITC}\frac{A_{nonsense}^n}{k^n+A_{nonsense}^n}){}^{\ast }off$
$on\to off$	$r_{off}$	$r_{off}^{\ast }on$
$on\to on+A^{\text{'}}$	$r_{prod}$	$r_{prod}^{\ast }on$
$A^{\text{'}}\to \varnothing$	$r_{deg}$	$r_{deg}^{\ast }{A}^{\text{'}}$
Gene B alleles
$off\to {on}^{(A)}$	$r_{add}^{A,B}\frac{A_{wt}^n}{k^n+A_{wt}^n}$	$(r_{add}^{A,B}\frac{A_{wt}^n}{k^n+A_{wt}^n}){}^{\ast }off$
$off\to {on}^{(A^{\text{'}})}$	$r_{add}^{A^{\text{'}},B}\frac{A^{{\text{'}}^n}}{k^n+A^{{\text{'}}^n}}$	$(r_{add}^{A^{\text{'}},B}\frac{A^{{\text{'}}^n}}{k^n+A^{{\text{'}}^n}}){}^{\ast }off$
${on}^{(A)}\to off$	$r_{off}$	$r_{off}^{\ast }{on}^{(A)}$
${on}^{(A^{\text{'}})}\to off$	$r_{off}$	$r_{off}^{\ast }{on}^{(A^{\text{'}})}$
${on}^{(A)}\to {on}^{(A)}+B$	$r_{prod}$	$r_{prod}^{\ast }{on}^{(A)}$
${on}^{(A^{\text{'}})}\to {on}^{(A^{\text{'}})}+B$	$\frac{r_{prod}}{d}$	${\frac{r_{prod}}{d}}^{\ast }{on}^{(A^{\text{'}})}$
$B\to \varnothing$	$r_{deg}$	$r_{deg}^{\ast }B$