Figure 2. Patterns of CSF $\text{M}\mathrm{\Psi }$ covariance.

Hypothesis-driven seed-based correlation analysis was conducted to investigate CSF flow covariance patterns. Similar seed-based correlation maps were observed in both OASIS-3 imaging cohorts (multi-b-value and b100 imaging cohorts). CSF $\text{M}\mathrm{\Psi }$ in the left and right Sylvian fissures displayed similar correlation patterns that demonstrated high bilateral symmetry. The correlation maps of the cerebral aqueduct and foramina of Monro $\text{M}\mathrm{\Psi }$ were similar, reflecting the common pathway for trans-ventricular CSF flow that included the third and fourth ventricles. Premedullary CSF $\text{M}\mathrm{\Psi }$ was positively correlated with CSF flow in the dorsal and ventral craniocervical junction columns extending to the cerebellopontine angles.

Abbreviations: CSF, cerebrospinal fluid; $\text{M}\mathrm{\Psi }$, mean pseudo-diffusivity.