Table 5.
Metrics of performance for predicting valid synthetic lethal targets against influenza infection using omics data from SARS-CoV-2 infections. The total number of non-redundant CRISPR-depleted candidate SL targets is 892.
| Data class | Enrichment of SL targets in CRISPR-depleted genes −log10(FDR-adjusted P-value) |
Sensitivity | Specificity | Precision |
|---|---|---|---|---|
| Transcriptome (down) | 3.07 | 0.51 | 0.54 | 0.09 |
| Transcriptome (up & down) | 3.07 | 0.52 | 0.53 | 0.09 |
| Virus-host PPI (BioID) | 2.22 | 0.34 | 0.69 | 0.09 |
| Proteome (up & down) | 1.9 | 0.28 | 0.75 | 0.09 |
| Proteome (up) | 1.83 | 0.18 | 0.84 | 0.1 |
| Transcriptome (up) | 1.83 | 0.34 | 0.69 | 0.09 |
| Proteome (down) | 1.43 | 0.19 | 0.83 | 0.09 |
| Virus-host PPI (AP) | 1.43 | 0.29 | 0.74 | 0.09 |
| Phosphoproteome | 1.34 | 0.24 | 0.78 | 0.09 |
| Ubiquitinome | 0.9 | 0.15 | 0.86 | 0.09 |
| RBP (up & down) | 0.81 | 0.05 | 0.96 | 0.1 |
| RBP (up) | 0.77 | 0.03 | 0.98 | 0.1 |
| RBP (down) | 0.71 | 0.03 | 0.98 | 0.1 |
| Cleavage | 0.63 | 0.03 | 0.97 | 0.1 |
| Virus-host RPI | 0.63 | 0.06 | 0.94 | 0.09 |
| Translatome (up) | 0.14 | 0 | 1 | 0.08 |
| Translatome (down) | 0.09 | 0.01 | 0.99 | 0.07 |
| Translatome (up & down) | 0.09 | 0.01 | 0.99 | 0.07 |