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[Preprint]. 2023 Aug 16:arXiv:2308.08618v1. [Version 1]

Table 3.

Dose-Response Curve Parameters and R² for Modeling the Dataset after Normalization and Scaling

	Brain-Cousens Model					Cedergreen Model
	Substrate Concentration (μM)					Substrate Concentration (μM)
Parameter	0.25	0.5	1	3	10	0.25	0.5	1	3	10
a	n/a	n/a	n/a	n/a	n/a	0.5087	0.4525	0.6523	0.7118	n/a
b	2.1953	1.7047	1.5782	1.3845	1.3130	1.8295	1.2634	0.9497	0.8706	n/a
c	0^a	0^a	0^a	0^a	0^a	0^a	0^a	0^a	0^a	n/a
d	100^b	100^b	100^b	100^b	100^b	100^b	100^b	100^b	100^b	n/a
e	3.6532	2.5803	2.9518	3.6051	11.3454	3.2534	7.2927	8.5220	26.2519	n/a
f	1.7762^c	65.6754	84.3791	74.5299	27.7673	23.4966^c	115.15	196.30	159.29	n/a
ED ₅₀	3.8745	15.6050	48.4562	287.64	4067.54	3.7651	16.1686	42.5023	132.39	n/a
M	0.1917	1.5531	2.4506	4.0958	16.8928	0.3879	1.3056	2.1720	3.9385	n/a
*LDS*	0.3707	5.4542	14.3082	47.1306	443.57	0.7988	5.6877	14.4126	41.3385	n/a
y _max	100.19	142.17	175.76	184.78	211.82	102.56	132.39	162.94	175.60	n/a
y _max %	100.19	142.17	175.76	184.78	211.82	102.56	132.39	162.94	175.60	n/a
R ²	0.9560	0.9259	0.8003	0.8499	0.9585	0.9538	0.9307	0.8098	0.8328	n/a
R ² _adjusted	0.9539	0.9224	0.7957	0.8464	0.9565	0.9516	0.9274	0.8055	0.8290	n/a

^a

parameter c was fixed

^b

parameter d was fixed

^c

f is not significantly different from zero based on the 95% confidence interval

Abbreviations: ND, not determined; n/a, not applicable