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. 2023 Aug 24;52(9):202–210. doi: 10.1038/s41684-023-01231-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The timings stated in each section of the figure indicate the duration of the corresponding phase of the disease. After exposure to SARS-CoV-2, a pre-symptomatic phase characterized by viral replication and early viral shedding precedes the onset of symptoms. The most common symptoms of acute COVID-19 are fever, cough, headache, dyspnea and fatigue; during this phase, the virus is still replicating, and the patient is contagious. In the weeks immediately after viral clearance, symptoms can either remit or persist. The common consensus for PCC is the persistence or new onset of symptoms three months after the beginning of the acute phase, which lasts for at least two months^1,19,95–97. Adapted from ref. ⁸², CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).