Table 2.
Shared neurological symptoms and lesions between PCC, Parkinson’s and Alzheimer’s diseases
| Condition | |||
|---|---|---|---|
| PCC | Parkinson’s disease | Alzheimer’s disease | |
| Symptoms | |||
| Headache | ✓ | – | – |
| Dizziness | ✓ | – | – |
| Anosmia | ✓ | ✓ | ✓ |
| Ageusia | ✓ | – | – |
| Anorexia | ✓ | – | – |
| Myalgia | ✓ | ✓ | – |
| Fatigue | ✓ | – | – |
| Bradyphrenia | ✓ | – | ✓ |
| Confusion | ✓ | – | ✓ |
| Memory loss | ✓ | – | ✓ |
| Impaired concentration | ✓ | – | ✓ |
| Sleep disorders | ✓ | ✓ | – |
| Depression | ✓ | ✓ | – |
| Lesions and study findings | |||
| Altered CSF cytokine profile | ✓ | ✓ | ✓ |
| Microglia activation | ✓ | – | ✓ |
| Astrocyte activation | ✓ | – | ✓ |
| T cell infiltration | ✓ | – | – |
| Excessive ROS | ✓ | ✓ | ✓ |
| Activated TGF-β pathway | ✓ | – | ✓ |
| Tau hyper-phosphorylation | ✓ | – | ✓ |
| α-Synuclein hyper-phosphorylation | ✓ | ✓ | ✓ |