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. 2023 Apr 13;44(9):1920–1931. doi: 10.1038/s41401-023-01083-w

Fig. 6. USP10 activates the CCND3 signaling pathway and promotes MM cell proliferation.

Fig. 6

a Lentiviral USP10 or empty virus (EV) was infected into OPM2 and KMS11 cells for 72 h, followed by cell lysate preparations and IB assays as indicated. b USP10 was knocked out or knocked down by using sgRNA or siRNA, respectively, for 72 h. Cells were then subjected to protein extraction and IB assays as indicated. CTL: control. OPM2 (c) and KMS11 (d) cells were subjected to USP10 knockdown by siRNA, 72 h later, cells were replated in 96-well plates. Cell proliferation was further measured by MTT assay at indicated time points. n.s., not significant; *P < 0.05, **P < 0.01.