Table III.
Results-cost description per NSCLC sample and patient (€ 2019).
| Step 1 - Pre-analysis | Step 2 - Analysis - Staining | Step 3 - Analysis - Molecular | Step 4 - Finalization and medical reporting | Total cost per sample | Total cost per patient | |
|---|---|---|---|---|---|---|
| Direct costs (%) | ||||||
| Practical nurse | € 0.28 (0.39%) | - | - | - | € 0.28 (0.04%) | € 0.48 (0.04%) |
| Administrative clerk | € 1.05 (1.46%) | - | - | - | € 1.05 (0.20%) | € 1.80 (0.20%) |
| Laborarory technician | € 42.29 (58.83%) | € 22.40 (12.04%) | - | € 48.08 (29.56%) | € 112.77 (17.09%) | € 193.93 (17.09%) |
| Graduated technician | - | € 5.63 (3.03%) | € 23.48 (16.06%) | - | € 29.11 (4.41%) | € 50.06 (4.41%) |
| Biologist | - | - | € 66.61 (20.56%) | € 15.41 (9.47%) | € 82.02 (12.43%) | € 141.05 (12.43%) |
| Pathologist | € 6.41 (8.91%) | - | - | € 64.90 (39.90%) | € 71.30 (10.81%) | € 122.62 (10.81%) |
| Biocassettes | € 0.88 (1.23%) | - | - | - | € 0.88 (0.13%) | € 1.52 (0.13%) |
| Slides | € 0.26 (0.37%) | € 0.75 (0.40%) | - | - | € 1.01 (0.15%) | € 1.74 (0.15%) |
| H&E reagent | - | € 0.41 (0.22%) | - | - | € 0.41 (0.06%) | € 0.71 (0.06%) |
| IHC staining reagent | - | € 7.96 (4.28%) | - | - | € 7.96 (1.21%) | € 13.68 (1.21%) |
| Predictive IHC staining reagent | - | € 72.44 (38.93%) | - | - | € 72.44 (10.98%) | € 124.58 (10.98%) |
| FISH stainers | - | € 32.11 (17.26%) | - | - | € 32.11 (4.87%) | € 55.23 (4.87%) |
| Special staining reagent + equipment | - | € 0.01 (0.01%) | - | - | € 0.01 (0.002%) | € 0.02 (0.002%) |
| Reagent + equipment | - | - | € 96.22 (40.24%) | - | € 96.22 (14.58%) | € 165.46 (14.58%) |
| Other reagents (formaline; alcool) | - | - | € 5.00 (2.09%) | - | € 5.00 (0.76%) | € 8.60 (0.76%) |
| Total direct cost (A) | € 51.17 (71.18%) | € 141.72 (76.16%) | € 191.31 (80.00%) | € 128.39 (78.93%) | € 512.58 (77.69%) | € 881.48 (77.69%) |
| Indirect costs (%) | ||||||
| Biocassette printers | € 1.43 (1.99%) | - | - | - | € 1.43 (0.22%) | € 2.46 (0.22%) |
| Sampler and citology hoods | € 0.66 (0.92%) | - | - | - | € 0.66 (0.10%) | € 1.14 (0.10%) |
| Cytocentrifuges | € 0.26 (0.37%) | - | - | - | € 0.26 (0.04%) | € 0.46 (0.04%) |
| Tissue processors | € 1.17 (1.62%) | - | - | - | € 1.17 (0.18%) | € 2.01 (0.18%) |
| Tissue embedding systems | € 0.57 (0.79%) | - | - | - | € 0.57 (0.09%) | € 0.98 (0.09%) |
| Microtome systems | € 2.25 (3.13%) | - | - | - | € 2.25 (0.34%) | € 3.87 (0.34%) |
| H&E stainers | - | € 1.16 (0.62%) | - | - | € 1.16 (0.18%) | € 1.99 (0.18%) |
| IHC stainers | - | € 5.99 (3.22%) | - | - | € 5.99 (0.91%) | € 10.30 (0.91%) |
| Microscope | - | - | - | € 1.75 (1.07%) | € 1.75 (0.27%) | € 3.01 (0.27%) |
| Total indirect cost (B) | € 6.34 (8.82%) | € 7.15 (3.84%) | € 0.00 (0.00%) | € 1.75 (1.07%) | € 15.24 (2.31%) | € 26.21(2.31%) |
| Overall (A) + (B) | € 57.51 (80.00%) | € 148.87 (80.00%) | € 191.31 (80.00%) | € 130.13 (80.00%) | € 527.81 (80.00%) | € 907.69 (80.00%) |
| Overheads a | € 14.38 (20.00%) | € 37.22 (20.00%) | € 47.83 (20.00%) | € 32.54 (20.00%) | € 131.95 (20.00%) | € 226.92 (20.00%) |
| Overall + overheads | € 71.88 (100.00%) | € 186.08 (100.00%) | € 239.13 (100.00%) | € 162.67 (100.00%) | € 659.77 (100.00%) | € 1134.61 (100.00%) |
a Overheads = [(A+B)*125%]-(A + B).