Table 1.

Demographic and clinical characteristics

	AIH alone		OS		Total
	n = 122		n = 20		n = 142		P‐value*
	Mean	SD	Mean	SD	Mean	SD
Age at diagnosis	51.7	12.9	49.2	15.9	51.3	13.3	0.436
	n	%	n	%	n	%
Female	113	92.6	17	85.0	130	91.5	0.256
Fatty liver	52	42.6	9	45.0	61	43.0	0.842
Autoimmune markers
High ANA at diagnosis	71	58.2	12	60.0	83	58.5	0.879
High Actin at diagnosis	90	73.8	9	45.0	99	69.7	0.009
High IgG at diagnosis	83	68.0	14	70.0	97	68.3	0.861
At least two positive markers at diagnosis	88	72.1	13	65.0	101	71.1	0.514
Controlled (most recent lab test)	75	61.5	9	45.0	84	59.2	0.165

Fibrosis at diagnosis (Metavir) (limited to patients with biopsy within 2 years of diagnosis and valid Metavir score)	AIH alone		OS		Total
	n = 107		n = 18		n = 125
	n	%	n	%	n	%	P‐value*
None (F0)	14	13.1	0	0.0	14	11.2	0.207
Mild (F1)	19	17.8	5	27.8	24	19.2
Moderate (F2)	31	29.0	3	16.7	34	27.2
Severe (F3)	28	26.2	8	44.4	36	28.8
Cirrhosis (F4)	15	14.0	2	11.1	17	13.6

TPMT enzyme activity	AIH alone		OS		Total
	n = 116		n = 19		n = 135
	n	%	n	%	n	%	P‐value*
Normal	102	87.9	16	84.2	118	87.4	0.674
Intermediate	12	10.3	3	15.8	15	11.1
Low	2	1.7	0	0.0	2	1.5

Symptoms at presentation	AIH alone		OS		Total
	n = 101		n = 17		n = 118
	n	%	n	%	n	%	P‐value*
Fatigue	53	52.5	8	47.1	61	51.7	0.679
Jaundice	42	41.6	5	29.4	47	39.8	0.343
Pruritis	14	13.9	3	17.6	17	14.4	0.681
Spider angioma	8	7.9	0	0.0	8	6.8	0.229
Splenomegaly	2	2.0	0	0.0	2	1.7	0.558

^*Comparing AIH alone to OS.

AIH, autoimmune hepatitis; ANA, antinuclear antibodies; IgG, immunoglobulin G; OS, overlap syndrome; TPMT, thiopurine methyltransferase.