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. 2023 Aug 12;21:4070–4078. doi: 10.1016/j.csbj.2023.08.007

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — The overall features of transmembrane kinases (TMKs) from different kingdoms. (A) The pipeline used for cross-kingdom identification of transmembrane kinases (TMKs). Model organisms were selected according to Hedges [15]. The profile hidden Markov models from Pfam-A were used for annotating three types of protein kinases (H, histidine; S/T/Y, serine/threonine/tyrosine; AA, amino acid) and other domains by HMMER v3.3.2. The transmembrane (TM) topology was predicted using the deepTMHMM server v1.0.13 (https://dtu.biolib.com/DeepTMHMM). (B) Comparison of the TMK proportions in the proteomes among five groupings. Different letters above the boxplots indicate significant difference (one-way ANOVA, n = 18–39). (C) The percentages of different TMK types (H, S/T/Y, and AA) in the five groupings. (D) Major TM topology types of TMKs in each grouping. N, amino-terminus; C, carboxyl-terminus; TM, transmembrane; ECD, extracellular domain.