Table 2. . Cross-comparison of fatty liver indices in populations examined with respect to diagnostic tool used to determine nonalcoholic fatty liver disease diagnosis.
| Study (Year) | Population (n) | Diagnosis method | AUROC (95% CI) | Ref. | ||||
|---|---|---|---|---|---|---|---|---|
| FLI | HSI | ZJU | FSI | FLDI | ||||
| Lee et al. (2010) | Korean adults (derivation cohort; n = 10,724) Korean adults (validation cohort; n = 5364) |
US | 0.783 0.786 |
0.812 (0.801–0.824) 0.819 (0.808–0.830) |
[12] | |||
| Wang et al. (2015) | Chinese adults (derivation cohort; n = 4800) Validation cohort (n = 4802) Second validation cohort (n = 148) |
US US Liver biopsy |
0.790 (0.778–0.803) | 0.793 (0.781–0.806) | 0.822 (0.810–0.834) 0.826 (0.815–0.838) 0.896 (0.818–0.974) |
[20] | ||
| Zhang et al. (2016) | Chinese hepatitis B patients (n = 364) | Liver biopsy | 0.753 (0.674–0.832) | 0.627 (0.546–0.707) | 0.780 (0.708–0.852) | [30] | ||
| Xia et al. (2016) | Chinese adults (n = 3548) | US | 0.76 (0.74–0.77) | 0.77 (0.75–0.78) | [29] | |||
| Li et al. (2017) | Chinese adults (n = 19,804) | Lab data + US | 0.873 (0.866–0.881) | 0.854 (0.846–0.863) | 0.925 (0.919–0.931) | [27] | ||
| Shen et al. (2017) | Chinese adults (coal-mining community; n = 4247) | US | 0.87 (0.86–0.88) | 0.83 (0.82–0.84) | 0.87 (0.86–0.88) | 0.85 (0.84–0.86) | [28] | |
| Zhu et al. (2018) | Chinese adults (n = 13,122) | US | 0.880 (0.874–0.886) | 0.833 (0.825–0.841) | 0.861 (0.854–0.868) | 0.864 (0.857–03871) | 0.874 | [36] |
| Chen et al. (2019) | Chinese sleep apnea patients (n = 431) | US | 0.802 (0.762–0.839) | 0.753 (0.710–0.793) | [35] | |||
| Cen et al. (2020) | Chinese adults (n = 21,468) | US | 0.849 (0.843–0.855) | 0.828 (0.822–0.834) | [31] | |||
| Jung et al. (2020) | Korean adults (n = 1301) | MRI | 0.68 (0.64–0.71) | 0.69 (0.66–0.73) | 0.69 (0.66–0.72) | 0.70 (66–0.73) | [23] | |
| Murayama et al. (2021) | Japanese adults (n = 1935) | US | 0.884 (0.876–0.892) | 0.874 (0.865–0.883) | 0.886 (0.877–0.894) | [33] | ||
| Shi et al. (2021) | Chinese pediatric patients (n = 1845) | US | 0.964 | 0.960 | [41] | |||
| DiBattista et al. (2022) | American adults (n = 701) | Imaging from EMR (US, CT or MRI) | 0.76 (0.72–0.79) | 0.78 (0.74–0.82) | [43] | |||
| Han and Lee (2022) | Korean adults (n = 1300) | CT | 0.791 (0.766–0.816) | 0.784 (0.758–0.809) | 0.704 (0.675–0.734) | [32] | ||
| Zhang et al. (2022) | Chinese adults (n = 3259) | US | 0.852 (0.839–0.864) | 0.847 (0.835–0.860) | 0.852 (0.839–0.864) | [30] | ||
AUROC: Area under receiver operating curve; CT: Computed tomography; EMR: Electronic medical records; FLDI: Fatty Liver Disease Index; FLI: Fatty Liver Index; FSI: Framingham Steatosis Index; HSI: Hepatic Steatosis Index; US: Ultrasound; ZJU: Zhejiang University Index.