Table 2.
Outcomes by the receipt of digoxin before hospital discharge in 1531 pairs of propensity score-matched patients with heart failure with left ventricular ejection fraction ≤45% who were not receiving digoxin before hospital admission (CI= confidence interval)
| Events (%) | Hazard Ratio Associated with Digoxin Use (95% confidence interval) | ||
|---|---|---|---|
| No digoxin (n=1531) | Digoxin (n=1531) | ||
| Heart failure readmission | |||
| 30 days | 166 (11%) | 125 (8%) | 0.74 (0.59–0.93); p=0.010 |
| 1 year | 550 (36%) | 471 (31%) | 0.81 (0.72–0.92); p=0.001 |
| 6 years | 769 (50%) | 737 (48%) | 0.90 (0.81–0.99); p=0.037 |
| All-cause readmission | |||
| 30 days | 364 (24%) | 332 (22%) | 0.90 (0.78–1.04); p=0.163 |
| 1 year | 1007 (66%) | 955 (62%) | 0.91 (0.83–0.99); p=0.029 |
| 6 years | 1296 (85%) | 1278 (84%) | 0.92 (0.85–0.99); p=0.041 |
| All-cause mortality | |||
| 30 days | 106 (7%) | 90 (6%) | 0.84 (0.64–1.12); p=0.230 |
| 1 year | 495 (32%) | 473 (31%) | 0.94 (0.83–1.07); p=0.360 |
| 6 years | 1048 (69%) | 1057 (69%) | 1.00 (0.92–1.09); p=0.990 |
| Heart failure readmission or all-cause mortality | |||
| 30 days | 253 (17%) | 207 (14%) | 0.80 (0.67–0.96); p=0.019 |
| 1 year | 856 (56%) | 788 (52%) | 0.87 (0.79–0.96); p=0.006 |
| 6 years | 1284 (84%) | 1268 (83%) | 0.92 (0.86–0.99); p=0.045 |
| All-cause readmission or all-cause mortality | |||
| 30 days | 422 (28%) | 388 (25%) | 0.91 (0.79–1.04); p=0.165 |
| 1 year | 1142 (75%) | 1098 (72%) | 0.92 (0.85–0.99); p=0.046 |
| 6 years | 1464 (96%) | 1454 (95%) | 0.93 (0.87–1.00); p=0.050 |