Fig. 1.

Two stages of the recruitment process. All historical data were pairwise harmonised to CHECK to train the cohort-specific models. These models were used to score each patient and construct a ranking of candidates for the screening visit. Up-to-date measurements taken at the screening visit were used by the screening model to generate the final ranking, from which ≈75% of patients were enrolled into the IMI-APPROACH cohort. Option to recruit new patients from outside of the existing cohorts was part of the contingency plan and rarely used (mainly in Oslo).