FIGURE 5.

IDO and TPH assay.
a.) TPH assay by LC-MS: Only L-Trp (positive control) is the substrate for the TPH enzyme.
b.) IDO1 assay: L-T13, L-T18, and L-Trp are substrates for the IDO1 enzyme. (﹡﹡﹡﹡ p < 0.0001)

IDO and TPH assay.
a.) TPH assay by LC-MS: Only L-Trp (positive control) is the substrate for the TPH enzyme.
b.) IDO1 assay: L-T13, L-T18, and L-Trp are substrates for the IDO1 enzyme. (﹡﹡﹡﹡ p < 0.0001)