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. Author manuscript; available in PMC: 2024 Mar 9.
Published in final edited form as: J Med Chem. 2023 Feb 24;66(5):3262–3272. doi: 10.1021/acs.jmedchem.2c01544

FIGURE 5.

FIGURE 5.

IDO and TPH assay.

a.) TPH assay by LC-MS: Only L-Trp (positive control) is the substrate for the TPH enzyme.

b.) IDO1 assay: L-T13, L-T18, and L-Trp are substrates for the IDO1 enzyme. (﹡﹡﹡﹡ p < 0.0001)