Table 2B.
Baseline characteristics and their associations with the improvement of therapeutic targets and the overall responses at week 8 in 63 refractory functional constipation patients treated with washed microbiota transplantation, as determined by univariate analyses
| Baseline characteristics | Improvement of therapeutic targets and overall response& | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Straining (27 vs. 33) |
Hard stools (26 vs. 31) |
Incomplete evacuation (6 vs. 8) |
Anorectal obstruction (5 vs. 4) |
Decreased stool frequency (28 vs. 18) |
Overall response (32 vs. 31) |
||||
| Sex | |||||||||
| Male (n = 29) | 46.0% | 55.6% vs. 57.6% | 53.8% vs. 54.8% | 66.7% vs. 50.0% | 80.0% vs. 75.0% | 50.0% vs. 44.4% | 56.3% vs. 51.6% | ||
| Female (n = 44) | 54.0% | 44.4% vs. 42.4% | 46.2% vs. 45.2% | 33.3% vs. 50.0% | 20.0% vs. 25.0% | 50.0% vs. 55.6% | 43.8% vs. 48.4% | ||
| Age, year | 60.8 ± 15.0 | 61.3 ± 12.0 vs. 59.7 ± 17.4 | 61.5 ± 11.7 vs. 59.8 ± 17.4 | 58.0 ± 15.9 vs. 67.5 ± 15.8 | 62.2 ± 7.7 vs. 71.5 ± 3.3 | 61.7 ± 12.2vs. 59.5 ± 18.7 | 60.3 ± 12.1 vs. 61.1 ± 17.6 | ||
| Duration of disease, year | 6 (2–12) | 7 (2–15) vs. 6 (2.5–13.5) | 10 (3–20) vs. 5 (1–10) | 2 (0.5–10) vs. 7.5 (1.75–17.5) | 3 (1.5–25) vs.6 (1.25–13.75) | 7 (3-18.75) vs.6 (1–10) | 7 (3-13.75) vs.6 (1–12) | ||
| Number of SCBMs/week | 2 (1–3) | 5 (4–6) vs.3 (2–3)* | 5 (3.75-6) vs.2 (2–3)* | 5.5 (4–7) vs.3.5 (2.25–6.75) | 4 (3–6) vs.4.5 (2.25–6.75) | 4 (3-5.75) vs.2 (1–2)* | 5 (3.25-6) vs.2 (2–3)* | ||
| BSFS score | 2 (1–2) | 4 (3–4) vs.2 (2–3)* | 3 (3–4) vs.2 (2–2)* | 3.5 (3-4.25) vs.2 (2-3.75)** | 3 (2.5–4.5) vs.2.5 (1.25–3.75) | 3 (3–4) vs.2 (1.75-2)* | 3.5 (3–4) vs.2 (2–2)* | ||
| Wexner constipation score | 9 (8–11) | 6 (4–7) vs.10 (8–11)* | 6 (4–7) vs.10 (8–11)* | 5.5 (3–8) vs.9 (6.5–10)** | 7 (3.5–12.5) vs.7.5 (3.25–9.5) | 6 (5.25–9.5) vs.10 (8-10.25)* | 6 (4–7) vs.10 (8–11)* | ||
| Course of WMT | 1 (1–3) | 2 (1–3) vs.1 (1–2)* | 2 (1–3) vs.1 (1–2)* | 3 (1–3) vs.1 (1–2) | 1 (1–3) vs.1 (1-1.75) | 2 (1–3) vs.1 (1–1)* | 2 (1–3) vs.1 (1–1)* | ||
| 1 (n = 37)# | 58.7% | 40.7% vs. 72.7% | 46.2% vs. 74.2% | 33.3% vs. 62.5% | 60.0% vs. 75.0% | 32.1% vs. 94.4% | 37.5% vs. 80.6% | ||
| 2 (n = 10) | 15.9% | 22.2% vs. 9.1%** | 19.2% vs. 12.9% | 0.0% vs. 25.0% | 0.0% vs. 25.0% | 21.4% vs. 5.6%* | 25.0% vs. 6.5%* | ||
| 3 (n = 16) | 25.4% | 37.0% vs. 18.2%* | 34.6% vs. 12.9%* | 66.75 vs. 12.5% | 40.0% vs. 0.0% | 46.4% vs. 0.0% | 37.5% vs. 12.9%* | ||
| Course of WMT ≥ 2 (n = 26) | 41.3% | 59.3% vs. 27.3%* | 53.8% vs. 25.8%* | 66.7% vs. 37.5% | 40.0% vs. 25.0% | 67.9% vs. 5.6%* | 62.5% vs. 19.4%* | ||
| History of laxative use | 76.2% | 63.0% vs. 84.8%** | 73.1% vs. 80.6% | 66.7% vs. 87.5% | 80.0% vs. 50.0% | 75.0% vs. 83.3% | 68.8% vs. 83.9% | ||
SCBMs/week, spontaneous complete bowel movements per week; WMT, washed microbiota transplantation; BSFS, Bristol Stool Form Scale;
&, responders vs. non-responders, responders were defined as those patients whose total scores decreased by 2 compared to the baseline;
#, one course of WMT was used as the reference, with which other (i.e., two, three, and two plus three) courses were compared, respectively;
Continuous data are presented as mean ± standard deviation or median with interquartile range, where appropriate, while categorical data are presented as number (percentage)
*, P < 0.05; **, P < 0.1