Table 4.
Influence of the courses of washed microbiota transplantation on major primary and secondary outcomes in functional constipation patients at weeks 8 and 24, as determined by multivariate logistic regression analysis
| Variable | At week 8 | At week 24 | ||
|---|---|---|---|---|
| Odds ratio (95% CI) | P-value | Odds ratio (95% CI) | P-value | |
| Primary outcomes | ||||
| Straining improvement rate | 4.458 (1.412–14.075) | 0.011 | 2.177 (0.693–6.836) | 0.183 |
| Hard stools improvement rate | 3.354 (1.101–10.222) | 0.033 | 2.182 (0.727–6.548) | 0.164 |
|
Decreased stool frequency improvement rate Overall response |
35.889 (4.109-313.423) 6.944 (2.215–21.776) |
0.001 0.001 |
4.897 (1.322–18.139) 3.782 (1.312–10.903) |
0.017 0.014 |
| Secondary outcomes | ||||
| Clinical remission rate | 4.571 (1.222–17.097) | 0.024 | 2.109 (0.558–7.975) | 0.272 |
| Clinical improvement rate | 10.214 (1.398–74.623) | 0.022 | 5.668 (1.436–22.363) | 0.013 |
WMT, washed microbiota transplantation; CI, confidence interval. Decreased stool frequency, fewer than three spontaneous complete bowel movements per week;
Comparison between two or more courses versus one course of WMT.