Table 2:

Structures and anti-ZIKV (FLV strain) activities of compounds 1, 20–43 in Vero cells.

Cpd #	R2	R6	% inhibition of ZIKV at 10 μM	% inhibition of ZIKV at 1 μM
1			99.9%	68.4%
20	same as above	-Cl	0	NT a
21	same as above	-OCH3	0	NT a
22	same as above		99.9%	90.0%
23	same as above		68.4%	NT a
24	same as above		99.0%	NT a
25	same as above		Cytotoxic	NT a
26	same as above		Cytotoxic	NT a
27	same as above		99.9%	90.0%
28	same as above		99.9%	90.0%
29	same as above		0	NT a
30	same as above		0	NT a
31	same as above		99.0%	NT a
32	same as above		96.8%	NT a
33	same as above		96.8%	NT a
34	same as above		96.8%	NT a
35			90.0%	NT a
36		same as above	99.0%	NT a
37		same as above	68.4%	NT a
38		same as above	99.7%	NT a
39		same as above	96.8%	NT a
40	same as above		Cytotoxic	NT a
41			99.9%	68.4%
42	same as above		99.0%	NT a
43	same as above	-OCH3	0	NT a

^aNot tested.