Table 3:

Structures and anti-ZIKV (FLV strain) activities of compounds 44–52 in Vero cells.

Cpd #	R3	R6	% inhibition of ZIKV at 10 μM	% inhibition of ZIKV at 1 μM
44	3-CH3		99.9%	0%
45	same as above		90.0%	NT a
46	same as above		99.9%	0%
47	3-OCH3		99.9%	90.0%
48	same as above		99.0%	NT a
49	same as above		99.9%	68.4%
50	3-CF3		99.0%	NT a
51	same as above		0%	NT a
52	same as above		68.4%	NT a

^aNot tested.