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. Author manuscript; available in PMC: 2024 Aug 10.
Published in final edited form as: J Med Chem. 2023 Jul 28;66(15):10746–10760. doi: 10.1021/acs.jmedchem.3c00924

Table 4:

Antiviral activity (EC50 in μM) against ZIKV and DENV.

ZIKV-FLR in Vero cells ZIKV-FLR in U87 cells ZIKV-FLR in C6/36 cells ZIKV-HN16 in Vero cells DENV-2 in Vero cells DENV-3 in Vero cells CC50 (μM) in U87 cells
22 0.90 ± 0.32 0.82 ± 0.09 0.75 ± 0.40 NT a 0.16 ± 0.04 NT a >20
27 0.18 ± 0.02 0.10 ± 0.022 0.23 ± 0.01 0.086 ± 0.057 0.21 ± 0.02 0.12 ± 0.07 >20
47 0.21 ± 0.01 0.69 ± 0.47 0.77 ± 0.41 NT a 0.56 ± 0.02 NT a >20
a

Not tested.