Table 3.
Mediation effect of CpG sites on the maternal BMI-child overweight or obesity (OWO) association in 903 mother–child pairs and 739 non-smoking during pregnancy mother–child pairs from the Boston Birth Cohort
| CpG | Gene | Outcome | Whole sample (N = 903) | Subset without maternal smoking (N = 739) | ||
|---|---|---|---|---|---|---|
| % Mediated | P | % Mediated | P | |||
| cg06292624 | AKAP7 | OWO at 13 years | 3.99 | 0.011 | 3.18 | 0.048 |
| OWO at 9 years | 4.38 | 0.007 | 3.52 | 0.047 | ||
| OWO at 8 years | 5.00 | 0.004 | 3.91 | 0.044 | ||
| OWO at 7 years | 5.04 | 0.007 | 4.40 | 0.038 | ||
| cg17886022 | LINC00174 | OWO at 13 years | 8.78 | 0.005 | 9.95 | 0.033 |
| OWO at 9 years | 9.36 | 0.002 | 10.71 | 0.019 | ||
| OWO at 8 years | 9.17 | 0.005 | 11.29 | 0.015 | ||
| OWO at 7 years | 8.98 | 0.010 | 11.53 | 0.022 | ||
| cg04347874 | NKX2-1 | OWO at 9 years | 8.58 | 0.005 | 0.43 | 0.610 |
| OWO at 8 years | 8.17 | 0.011 | 0.35 | 0.630 | ||
| OWO at 7 years | 8.94 | 0.005 | 0.60 | 0.600 | ||
| cg04390217 | PECR | OWO at 13 years | 5.95 | 0.006 | 2.60 | 0.080 |
| OWO at 9 years | 5.14 | 0.011 | 2.10 | 0.100 | ||
| OWO at 8 years | 5.30 | 0.013 | 2.01 | 0.120 | ||
| cg09545197 | KCNA3 | OWO at 8 years | 13.35 | 0.016 | 3.13 | 0.180 |
| OWO at 7 years | 15.83 | 0.007 | 3.89 | 0.170 | ||
| cg13331383 | TMEM203 | OWO at 7 years | 5.66 | 0.016 | 8.68 | 0.036 |
| NDOR1 | OWO at 5 years | 8.22 | < 0.001 | 11.53 | 0.001 | |
| cg04383707 | NCCRP1 | OWO at 13 years | 4.67 | 0.006 | 2.14 | 0.110 |
| cg08391482 | SERBP1 | OWO at 13 years | 10.57 | 0.010 | 1.25 | 0.250 |
| cg01886035 | CGREF1 | OWO at 9 years | 4.32 | 0.009 | 1.07 | 0.320 |
| cg14015044 | TNFRSF10C | OWO at 8 years | 25.21 | 0.010 | 30.75 | 0.010 |
| cg23732384 | MAP2K7 | OWO at 7 years | 10.19 | 0.016 | 15.80 | 0.003 |
| cg02059896 | (PIKFYVEa) | OWO at 3 years | 21.69 | < 0.001 | 1.64 | 0.490 |
| cg14257335 | KLHL22 | OWO at 3 years | 17.41 | 0.004 | 19.79 | 0.002 |
| cg15059222 | CAMK2B | OWO at 3 years | 14.88 | 0.003 | 2.80 | 0.150 |
All models adjusted for maternal age, education level, race, parity, smoking (only in analysis among whole mother–child pairs), alcohol consumption, gestational age, child sex, birthweight, cord blood cell compositions (CD8, CD4, N.K., B cell, monocytes, granulocytes, nucleated red blood cells), and all surrogate variables
aFor inter-genic CpG sites, we used the UCSC Genome Browser on Human (GRCh37/hg19) to locate the nearest annotated gene