Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 26;21:575. doi: 10.1186/s12967-023-04432-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 11 — Effect of GPX3 on autophagy and ferroptosis of prostate in vivo. Representative IHC images of GPX4 A and Nrf2 B in prostate of Con, testosterone (T), T + RAS-selective lethal 3 (RSL3), T + troglitazone (TRO) and T + RSL3 + TRO-treated rats group. The quantitative analysis of GPX4 C and Nrf2 D expression in each group rat prostates. E Relative densitometric quantification of GPX4, Nrf2, SOD2 and CAT in prostate of each treatment group. The content of iron F, MDA G and GSH H in prostate of each treatment group were detected by colorimetric assay kit. The results indicated that the ferroptosis and OS levels in the prostate of T-BPH rats could be aggravated by RSL3 treatment, while inhibited by up-regulation of GPX3 in vivo. Representative IHC images of LC3B I and Beclin1 J in prostate of each treatment group. The quantitative analysis of LC3B K and Beclin1 L expression in each group rat prostates. M Relative densitometric quantification of LC3B and Beclin1 in prostate of each treatment group. The results showed that the autophagy level in the prostate of T-BPH rats could be aggravated by RSL3 treatment, while inhibited by up-regulation of GPX3 in vivo. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. The scale bars are 400 μm