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. 2023 Aug 26;21:575. doi: 10.1186/s12967-023-04432-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — The levels of apoptosis, OS, ferroptosis and autophagy in normal and hyperplastic prostates A Representative IHC images of BAX, Caspase 3 and Bcl-2 in human prostate tissues. The scale bars are 200 μm. B The quantitative analysis of BAX, Caspase 3 and Bcl-2 expression in human prostate tissues. C Immunoblot assay (i) and relative densitometric quantification (ii) revealed the protein expression of BAX, Caspase 3 and Bcl-2 in normal prostate tissues (n = 4) and BPH tissues (n = 4). The results showed that there was a lower level of apoptosis in human hyperplastic prostate. D Representative IHC images of GPX4 and Nrf2 in human prostate tissues. The scale bars are 400 μm. E The quantitative analysis of GPX4 and Nrf2 expression in human prostate tissues. F Representative IHC images of CAT and SOD2 in human prostate tissues. The scale bars are 200 μm. G The quantitative analysis of CAT and SOD2 expression in human prostate tissues. H Immunoblot assay (i) and relative densitometric quantification (ii) revealed the protein expression of GPX4, Nrf2, CAT and SOD2 in normal prostate tissues (n = 4) and BPH tissues (n = 4). The results showed that there were higher levels of ferroptosis and OS in human hyperplastic prostate. I Immunoblot assay (i) and relative densitometric quantification (ii) revealed the protein expression of LC3B and Beclin1 in normal prostate tissues (n = 4) and BPH tissues (n = 4). J Representative IHC images of Beclin1 and LC3B in human prostate tissues. The scale bars are 200 μm. K The quantitative analysis of Beclin1 and LC3B expression in human prostate tissues. The results showed that there was a higher level of autophagy in human hyperplastic prostate. GAPDH is used as loading control. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001