Table 1.

Summary of inclusion and exclusion criteria

Inclusion	Exclusion
English language	Not in English or partial content in English
Randomized control study published in peer-reviewed journals in any region of the world	Case studies, cross-sectional designs, cohort studies, quasi-experimental designs or cross-over designs
Non-pharmacological interventions	Pharmacological, acute clinical care, or Surgical interventions
Adults (≥ 18 y.o)	Children (< 18 y.o)
Patients with a clinical diagnosis of multiple sclerosis—all types and severities	Patients with additional comorbidities as specified in the inclusion criteria of the study
Studies measuring of Quality of Life at baseline and at least one time point after, for both arms utilizing MSQOL-54, SF-36 or the MSQLI	Studies not providing sufficient statistical data on pre- and post-QoL test scores such as SD, SE or P-values
Full text manuscript/publication	Abstracts, reviews, conference presentations