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. 2023 Aug 26;21:298. doi: 10.1186/s12951-023-02063-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — DSPE-PEG encapsulated hydrophobic iron oxide nanocubes for targeted MRI detection. (A) Schematic illustration of improving the colloidal stability and biocompatibility of hydrophobic nanocubes using DSPE-PEG. (B) Prussian blue staining of RAW264.7 cells cultured without (I) or with (II) MFRN. Cells were stained in red and MFRN in the cytoplasm was stained in blue. (C) In vivo 7 Tesla cardiac MR images before and 24 h after intravenous injection of MFRN, and with or without external magnetic exposure measures. White arrows point to infarcted tissue. (D) Negative contrast is stronger with injection of MFRN and with magnetic exposure. Reproduced with permission [135]. Copyright 2016, Wiley-VCH