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. 2023 Aug 23;23:789. doi: 10.1186/s12885-023-11239-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — ACADM knockdown enhanced the FA-triggered cytotoxic effects of gemcitabine by inducing ferroptosis. (A) Cell viability after treatment with palmitic acid (PA) at different concentrations and gemcitabine. (B) Cell viability after treatment with palmitoleic acid (POA) at different concentrations and gemcitabine. (C) Cell viability after treatment with linolenic acid (LA) at different concentrations and gemcitabine. (D) The MDA level of PC cells after different fatty acid and gemcitabine treatments. (E) The MDA level of PC cells after FA6-152 and gemcitabine treatment. (F) The MDA level of PC cells with ACADM overexpression. (G) ACADM overexpression PC cells viability after treatment with fatty acid. (H) ACADM knockdown PC cells viability after treatment with fatty acid. (I) Cells viability after treatment with fatty acid and erastin. (J) Cell viability of PC cells treated with gemcitabine and palmitic acid (100umol) vs. the untreated control. (K) Cloning of pancreatic cancer cells treated with gemcitabine and palmitic acid. (L) Cell viability of PC cells treated with gemcitabine and palmitic acid(100umol) of each group