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. 2023 Aug 23;23:789. doi: 10.1186/s12885-023-11239-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — ACADM knockdown enhanced the FA-triggered cytotoxic effects of gemcitabine by inducing ferroptosis (A) Heatmap of differential genes after knockdown of ACADM. (B) Gene set enrichment analysis of drug metabolism, oxidative phosphorylation, and fatty acid biosynthesis-related genes in ACADM knockdown cell vs. the control group. (C) Fatty acid peroxisome level of PC cells after ACADM knockdown or overexpression under gemcitabine treatment. (D) ROS level and mean fluorescence intensity (MFI) of pancreatic cancer cells. (E) Cell viability of PC cells after treated with or without NAC or knockdown of ACADM. (F) The level of glutamine metabolism signature expression was detected in sh-control and sh-ACADM cells by qPCR. (G) The GPX4 level of each PC cells were detected by WB. (H) Cell viability of PC cells after ACADM knockdown and GPX4 overexpression. (I) Cell viability of PC cells in different GEM concentration after treated with Fer-1 or GPX4 overexpression. (J) The concentration of glutathione (GSH) was assayed