Table 2.
GPCR mutations selected
| GPCR | PDB | GPCRmd ID | Mutation | GPCRdb ligands/datapoints | GDC patients | Motif |
|---|---|---|---|---|---|---|
| AA1R | 5UEN | 165 | T277A7.41 | 13/36 | 0 | – |
| R291C7.56 | 4/4 | 1 | NpxxY (ext) | |||
| R296C8.51 | 4/4 | 1 | – | |||
| AA2AR | 5IU4 | 49 | I66A2.64 | 20/22 | 0 | – |
| L85A3.33 | 21/21 | 0 | – | |||
| T88D3.36 | 14/16 | 0 | – | |||
| S91A3.39 | 12/16 | 0 | – | |||
| L167A45.51 | 20/20 | 0 | – | |||
| M177A5.40 | 22/24 | 0 | – | |||
| N181A5.43 | 20/20 | 0 | – | |||
| W246A6.48 | 37/52 | 0 | CWxP | |||
| N253A6.55 | 22/22 | 0 | – | |||
| Y271A7.35 | 20/22 | 0 | – | |||
| S277A7.41 | 29/33 | 0 | – | |||
| H278N7.42 | 3/3 | 1 | – | |||
| ACM2 | 3UON | 111 | D103E3.32 | 32/42 | 0 | – |
| D103N3.32 | 12/15 | 0 | – | |||
| V421L7.33 | 1/1 | 1 | – | |||
| ADRB2 | 2RH1 | 11 | D79N2.50 | 12/12 | 0 | – |
| D130N3.49 | 11/11 | 0 | DRY | |||
| S203A5.43 | 12/12 | 0 | – | |||
| S204A5.44 | 13/13 | 0 | – | |||
| N293L6.55 | 12/12 | 0 | – | |||
| V317A7.43 | 5/5 | 1 | – | |||
| CCR5 | 4MBS | 118 | Y108A3.32 | 12/20 | 0 | – |