. 2023 Aug 29;21:79. doi: 10.1186/s12958-023-01126-1

Table 4.

Study characteristics of 2 studies about Vitamin supplementation impact on fertility

Study	Country	Study type	Sample size(intervention/control)	Age(Mean ± SD)	Type and duration of supplementation	outcome
Xiang Lu et al.,2018	China	RCT	137/108	Intervention: 31.5 ± 3.5 Control:31.9 ± 3.00	Vitamin C 1000 mg/ day of 2mo	Non-treatment	retrieved oocyte rate, implantation rate, and clinical pregnancy rate unaffected;but ameliorating the quality of oocytes and embryos
Jennifer Mier-Cabrera et al;2007 [37]	Mexico	RCT	(16/18)	Intervention: 32.7 ± 2.36 Control: 32.8 ± 2.49	vitaminE84mg + vitaminC343mg for 6	Placebo pills for 6weeks	the pregnancy rate unaffected

Study

Country

Study type

Sample size(intervention/control)

Age(Mean ± SD)

Type and duration of supplementation

outcome

Intervention group

Placebo group

Xiang Lu et al.,2018

China

RCT

137/108

Intervention: 31.5 ± 3.5 Control:31.9 ± 3.00

Vitamin C 1000 mg/ day of 2mo

Non-treatment

retrieved oocyte rate, implantation rate, and clinical pregnancy rate unaffected;but ameliorating the quality of oocytes and embryos

Jennifer Mier-Cabrera et al;2007 [37]

Mexico

RCT

(16/18)

Intervention: 32.7 ± 2.36

Control: 32.8 ± 2.49

vitaminE84mg + vitaminC343mg for 6

Placebo pills for 6weeks

the pregnancy rate unaffected