Predictive marker class	Predictive accuracy > 0.5	Feature relation to target	Feature importance	Feature type	Dep.- Feature Correlation direction	Dep. Skewness
Genetic driver	Any model	Self	Normalized feature importance > 0.05	Hotspot or missense mutation, fusion, copy number	Negative (CN), Positive (Mut.)	Negative
Expression addiction	Model using self exp. feat	Self	Top feature of model	RNAseq	Negative
Synthetic lethal (paralog)	Model using paralog as top feature	Other (paralog)	Top feature	Any	Any
CYCLOPS	Model using self exp. feat	Self	Top feature on same chr. arm and self-feature has normalized feature importance > 0.05	Copy number OR RNAseq	Positive cor. to top feature AND positive cor. to self CN	Negative
Oncogene addiction	Any model	Self (oncogene from oncoKB.org)	Top 10 of unbiased or related model	Any	Any	Negative
Synthetic lethal (oncogene/TSG)	Model using oncogene or TSG feature	Other (oncogene or TSG from oncoKB.org)	Normalized feature importance > 0.05	Any	Any	Negative