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. 2023 Aug 22;21:286. doi: 10.1186/s12951-023-02013-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — ¹H NMR spectrum of CA-Oxi-αCD carrier and the characterization of DTX/CA-Oxi-αCD NPs and DTX/FA-CA-Oxi-αCD NPs. (A) ¹H NMR spectrum of CA-Oxi-αCD carrier. (B) Size distribution and morphology of Blank NPs, DTX/CA-Oxi-αCD NPs and DTX/FA-CA-Oxi-αCD NPs. (C) The change of morphology of DTX/FA-CA-Oxi-αCD NPs in various medium. (D) The intracellular concentration of H₂O₂ in 4T1 cells after different treatment. The controls were treated with cell culture medium. *p < 0.05, **p < 0.01, compared with CA-Oxi-αCD NPs (n = 3). (E) The in vitro drug release behavior of DTX/CA-Oxi-αCD NPs (a,c) and DTX/FA-CA-Oxi-αCD NPs (b,d) in various release medium for 48 h. (a,b) The released DTX. (c,d) The released CA. Data represent mean ± SD (n = 3)