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. 2023 Aug 22;21:286. doi: 10.1186/s12951-023-02013-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — In vivo antitumor and antimetastasis efficacy evaluation. (A) Scheme illustration of the in vivo antitumor experiment design. (B) Tumor growth curves after intravenous injection of free DTX and various NPs. (C) Representative photographs of tumor tissue from mice in different groups. (D) The tumor weight of mice in different groups. (E) The DTX concentration in major tissues of different groups. (F) The survival rate of mice after various treatment. (G) Representative images of lung tissues harvested from mice in different groups and histological examination of the pulmonary metastatic foci in different groups by H&E staining. Scale bar represents 100 μm. (H) Immunohistochemistry assay for CD 8⁺ (upper panel) and CD 4⁺ ((lower panel) in tumor tissues. Scale bar represents 100 μm or 50 μm, respectively. (I) (a) The number of visually detected metastatic nodules in the lungs of different groups, (b) The inhibition rate on lung metastasis of different groups. (J) (a) The semi-quantitative analysis of the CD8⁺ expression and (b) CD4⁺ expression in tumor tissues from mice after different treatments. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001, compared with DTX/FA-CA-Oxi-αCD NPs. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 and ^####p < 0.0001, compared with DTX/CA-Oxi-αCD NPs