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. 2023 Aug 22;21:286. doi: 10.1186/s12951-023-02013-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — In vivo bioluminescent distribution of the mice treated with PBS, Blank NPs, DTX, DTX/CA-Oxi-αCD NPs and DTX/FA-CA-Oxi-αCD NPs at the same doses of 5 mg/kg of DTX (n = 5). (A) Scheme illustration of the pulmonary metastasis inhibition experiment design. (B) In vivo bioluminescent images of the mice treated with DTX and various NPs. (C) The bioluminescence images of the ex vivo major organs from mice after different treatments. (D) Bioluminescence intensity in the lung of mice after different treatments in vivo. (E) Bioluminescence intensity of the ex vivo lungs in the mice after different treatments. (F) The photo images of ex vivo lungs in the mice treated with DTX and various NPs. (G) Representative microphotographs of H&E sections of lungs in the mice treated with DTX and various NPs. Scale bar represents 50 μm. (I) PBS, (II) Blank NPs, (III) DTX, (IV) DTX/CA-Oxi-αCD NPs, (V) DTX/FA-CA-Oxi-αCD NPs. *p < 0.05, **p < 0.01, and ***p < 0.001, compared with DTX/ FA-CA-Oxi-αCD NPs (n = 5)